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The chaperone function of Tsa1 prevents the accumulation of misfolded ribosomal proteins under reductive stress, which occurs when Tsa1 is present in the cytoplasm (Dauplais et al., 2021

For the series of processes required, Gln uptake is a fundamental step highly regulated by the extracellular signal-regulated kinases (ERK)/MAPK pathway (Figure 12)